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In this group, we could observe the pattern of use during the first 2 years of benzodiazepine use.The prevalent long-term users group ( = 992) contained subjects who received prescriptions for benzodiazepines in the 6 months prior to baseline and who continued the use of benzodiazepines for at least 6 months after this period.The incidence of escalation to a higher dosage was 1.6%.
Tolerance develops faster for benzodiazepines with a shorter half-life than for those with longer half-life periods.Tolerance towards the anxiolytic effects has been shown inconsistently in various animal and human studies, and when detected, it appears to occur at a slower rate and to a lesser extent than sedative tolerance.The development of tolerance towards the effects of benzodiazepines raises the expectation that long-term benzodiazepine users have to increase their dose over time to experience the same effect.Nevertheless, long-term benzodiazepine use is still highly prevalent in Western communities.Depending on the definition for ‘long-term benzodiazepine users’, the prevalence rates of long-term benzodiazepine use in the general population vary between 1% (daily use for at least 1 year) and 3% (use for 6 months) benzodiazepine users experience symptoms of withdrawal (e.g. Withdrawal symptoms are responsible for continuation of use when subjects interpret them as return of original symptoms.
Long-term benzodiazepine users who had received prescriptions of benzodiazepines for daily use within the first 6 months of the observation period were selected for the present study.